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e-ISSN 1828-1427

  

Rivista trimestrale di Sanità Pubblica Veterinaria edita dall'Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise "G. Caporale"

A quarterly journal devoted to veterinary public health, veterinary science and medicine published by the Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise ‘G. Caporale’ in Teramo, Italy

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2005 - Volume 41 (3) July-September
   
 
M.A. Ramakrishnan, A.B. Pandey, K.P. Singh, R. Singh & M.L. Mehrotra
Immune response and protective efficacy in sheep immunised with hydroxylamine-inactivated bluetongue virus vaccine  149-155
       

Summary
Vero cell adapted bluetongue virus (BTV), serotype 18 (BTV-18) was inactivated with hydroxylamine and adjuvanted with aluminium hydroxide (Al[OH]3) gel, saponin, or Al(OH)3 gel/saponin prior to immunisation of sheep. Group-specific non-neutralising antibodies to BTV were detected in all vaccinated sheep as soon as seven days after vaccination. However, before challenge, serotype-specific neutralising antibodies were not detected in vaccinated sheep. Upon challenge with homologous live BTV, there was a reduction in delayed type of hypersensitivity response in control sheep but not in the vaccinated animals. All vaccinated sheep had significant (P<0.01) reductions in their clinical reaction index (CRI) and duration of viraemia.

Keywords
Bluetongue virus, Clinical reaction index, Delayed type of hypersensitivity, Hydroxylamine, Immune response, Immunosuppression, Vaccines.


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