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e-ISSN 1828-1427

  

Rivista trimestrale di Sanità Pubblica Veterinaria edita dall'Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise ‘G. Caporale’

A quarterly journal devoted to veterinary public health, veterinary science and medicine published by the Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise ‘G. Caporale’ in Teramo, Italy

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2015 - Volume 51 (1), January-March
   
 
Yuvaraj Shanmugam, Madhanmohan Muthukrishnan, Nagendrakumar Balasubramanian Singanallur & Srinivasan Alwar Villuppanoor  
Phylogenetic analysis of the leader proteinase (Lpro) region of Indian foot and mouth disease serotype O isolates 31-37
doi: 10.12834/VetIt.164.473.2
 
Summary
In this study, the nucleotide sequences of the complete leader proteinase (Lpro) region of 21 isolates of foot-and-mouth disease virus (FMDV) serotype O collected during various outbreaks in India were sequenced and compared with vaccine strains. The phylogenetic analysis of these Lpro sequences showed a difference in the clustering of the isolates based on the VP1 capsid coding region sequences. The comparison of amino acid sequences at the N terminus end of the Lpro region showed very high variability, although 2 conserved start codons (AUG) at 1st and 29th sites. Furthermore, all the amino acid residues that formed the active cleft site of the Lpro sequences of this study were conserved. These results suggest that Lpro sequences could also be used for phylogenetic comparison of FMDV isolates.

Keywords
Foot-and-mouth disease virus, Leader proteinase (Lpro), Phylogenetic analysis, Serotype O.


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