animals and their human guardians suffer from many of the same types
of cancer and are often treated with many of the same drugs. Moreover,
the overall tumour biology is much more similar between humans and
companion animals than between humans and rodent tumor models. Therefore,
it is proposed that pre-clinical evaluation of novel cancer therapeutics
should more often include appropriately designed trials in companion
animals with cancer to more accurately predict efficacy and toxicity
in humans. For example, studies in dogs with cancer have been used
to assess efficacy and design human clinical trials of immunotherapy,
gene therapy, sustained release drug delivery and liposomal drug
delivery. In the future, such studies will ultimately benefit not
only humans, but also companion animals with cancer.
Biology, Canine, Cancer, Chemotherapy, Immunotherapy, Model, One
Health, Pet, Public health, Trial, Toxicity, Tumour.