Summary
Hepatitis
E is an infectious viral disease with clinical and morphological
features of acute hepatitis. The aetiological agent is the hepatitis
E virus (HEV). The disease represents an important public health
problem in developing countries where it is frequently epidemic
and is primarily transmitted by the faecal-oral route. In recent
years, a number of sporadic cases have also been described in industrialised
countries, Italy included. Swine HEV was first identified in 1997
and is now considered a ubiquitous virus. Human and swine strains
from the same region have been shown to have a high level of nucleotide
homology and, in experimental infections, the possibility of cross-species
transmission of swine strains to humans and of human strains to
non-human primates has been demonstrated. Furthermore, some seroepidemiological
studies have demonstrated that people working in contact with swine
have a higher risk of infection than regular blood donors. Recently,
cases of HEV hepatitis in Japan were directly associated with the
ingestion of uncooked meat from pigs, wild boar or deer and today
the disease is considered an emerging zoonosis. The authors summarise
current virological and epidemiological knowledge on HEV infections
so as to stimulate interest in a virus that has not received much
attention in veterinary medicine, but that could become an important
zoonotic agent.
Keywords
Animal
diseases, Hepatitis E, Pigs, Public heath, Viruses, Zoonoses. |