Today, international cooperation is one of the principal activities of the Institute, which collaborates increasingly closely with international institutions and organizations such as the EU, the OIE, the WHO and the FAO.

In the last few years there have been innumerable cooperation projects through which the Institute has put its technical-scientific skills and knowledge at the disposal of European and non-European countries. The European Union, the Government of the United States of America and numerous countries in Latin America and Africa have expressed a high degree of confidence in to the Istituto G. Caporale. Suffice it to mention the development of programmes of management and technical consultancy in Argentina, the creation and fine-tuning of diagnostic laboratories in Namibia and the design of cutting-edge training courses in Chile, including those in eLearning mode The quality and skill demonstrated by the Institute are attested both by the commissions with which it has been entrusted by beneficiary countries, and by the international tender contracts which it has won during the course of EU programmes.

In 2007, for example, specialists from the various sectors took part in more than 250 international missions, and the adjudication of international tender competitions sponsored by the EU and other public institutions provided funding for activities worth more than 7 million Euros.

The future will be played out increasingly in the field of innovation and development strategies aimed, especially, at consolidating the priority objective: the safeguarding of human health. Increasingly, the necessary condition for achieving this objective is the possession of knowledge and experience allowing interaction with the integrated system "animal welfare - animal health   - food safety".

The international vocation of the Institute has always been founded on a sense of ethical responsibility which derives from the awareness of the risks involved in the trade in animals and their products on a scale expanded and diversified by globalization.

The Institute's firm commitment to international cooperation has led a number of deputies from different political parties to request the Italian government to undertake to adopt the necessary regulatory measures to recognize the Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise G. Caporale as a "Valuable body of national importance and an outstanding operational asset of the Ministry of Health because of its European and international activities for cooperation and high-level education [ ... ] with particular reference to the expansion of its international activities of research, cooperation and training of staff of public and private institutions, and the performance of services in the fields of food safety, international veterinary preventive medicine and related matters [ ... ] ".

The Institute is recognized by the European Union as one of the channels for delivering technical assistance to candidate and potential candidate countries for EU membership, and also for Twinning projects.

The latest international recognition of a certain weight occurred in 2007 when the Ministry of Health appointed a veterinary manager from the Institute to the post of Director of the Central Veterinary Laboratory of Namibia at Windhoek, for the purpose of organizing the Laboratory and training the Namibian staff to high scientific standards.